THE HYPOXIA-DRIVEN CROSSTALK BETWEEN TUMOR AND TUMOR-ASSOCIATED MACROPHAGES: MECHANISMS AND CLINICAL TREATMENT STRATEGIES

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which invertatop squeeze bottle have a la

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Operator Suspicion and Human-Machine Team Performance Under Mission Scenarios of Unmanned Ground Vehicle Operation

Emergent cyber-attack threats against cyber-physical systems can create potentially catastrophic impacts.The operators must intervene at the right moment when suspected attacks occur, without over-reliance on systems to detect the cyber-attacks.However, military operators are normally trained to trust, rather than suspect systems.We applied suspici

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Effectiveness of different databases in identifying studies for systematic reviews: experience from the WHO systematic review of maternal morbidity and mortality

Abstract Background Failure to be comprehensive can distort the results of a systematic review.Conversely, extensive searches may yield unmanageable number of citations of which only few may be relevant.Knowledge of usefulness of each source of information may help to tailor search strategies in systematic reviews.Methods We cent dyyni conducted a

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Emotional Egocentricity Bias across the life-span

In our daily lives, we often have to quickly estimate the emotions of our conspecifics in order to have successful social interactions.While this estimation process seems quite easy when cent dyyni we are ourselves in a neutral or equivalent emotional state, it has recently been shown that in case of incongruent emotional states between ourselves a

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